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首頁 > 抗體 > 兔單抗 > Akt (pan) (Phospho Ser473) (PT0470R) PT® Rabbit mAb
Akt (pan) (Phospho Ser473) (PT0470R) PT® Rabbit mAb
商品貨號： PLR10305
適 應 性： 人,小鼠,大鼠,
WB IHC IF ELISA IP
￥1200元
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  • 靶點-Target： Akt1/2/3
  • MW(Calculated)： 55kD
  • MW(Observed)： 60kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 修飾-Modification： Phospho
  • 修飾位點： Ser473
  • 推薦稀釋比： IHC 1:200-1:500;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性： Monoclonal
  • 克隆號： PT0470R
  • 特異性： This antibody detects endogenous levels of Phospho Akt1 only when phosphorylated at Ser473. This antibody also recognizes Akt2 and Akt3 when phosphorylated at the corresponding sites.
  • 基因名稱： AKT1/AKT2/AKT3
  • 蛋白名稱： RAC-alpha serine/threonine-protein kinase;RAC-beta serine/threonine-protein kinase;RAC-gamma serine/threonine-protein kinase
  • Organism-1： 人
  • 基因ID-1： 207;208;10000
  • SwissProt-1： P31749;P31751;Q9Y243
  • Organism-2： Mouse
  • 基因ID-2： 11651;11652;23797
  • SwissProt-2： P31750
  • Organism-3： Rat
  • 基因ID-3： 24185;25233;29414
  • SwissProt-3： P47196;P47197;Q63484
  • 細胞定位： Cytoplasm . Nucleus . Cell membrane . Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529). .
  • 組織表達： Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all 人 cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
Akt (pan) (Phospho Ser473) (PT0470R) PT® Rabbit mAb
Catalog No PLR10305
Product information
  • 靶點-Target： Akt1/2/3
  • MW(Calculated)： 55kD
  • MW(Observed)： 60kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 修飾-Modification： Phospho
  • 修飾位點： Ser473
  • 推薦稀釋比： IHC 1:200-1:500;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性： Monoclonal
  • 克隆號： PT0470R
  • 特異性： This antibody detects endogenous levels of Phospho Akt1 only when phosphorylated at Ser473. This antibody also recognizes Akt2 and Akt3 when phosphorylated at the corresponding sites.
  • 基因名稱： AKT1/AKT2/AKT3
  • 蛋白名稱： RAC-alpha serine/threonine-protein kinase;RAC-beta serine/threonine-protein kinase;RAC-gamma serine/threonine-protein kinase
  • Organism-1： 人
  • 基因ID-1： 207;208;10000
  • SwissProt-1： P31749;P31751;Q9Y243
  • Organism-2： Mouse
  • 基因ID-2： 11651;11652;23797
  • SwissProt-2： P31750
  • Organism-3： Rat
  • 基因ID-3： 24185;25233;29414
  • SwissProt-3： P47196;P47197;Q63484
  • 細胞定位： Cytoplasm . Nucleus . Cell membrane . Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529). .
  • 組織表達： Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all 人 cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
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