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PHF8 rabbit pAb
商品貨號(hào)： PLA021567
適 應(yīng) 性： 人,小鼠
WB IHC
￥600元
規(guī)格：
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MSDS
說(shuō)明書(shū)
商品描述
  • 基因名稱(chēng)： PHF8 KIAA1111 ZNF422
  • 蛋白名稱(chēng)： Histone lysine demethylase PHF8 (EC 1.14.11.27) (PHD finger protein 8)
  • Human_gene_id： 23133
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23133
  • Human_swiss_prot_no： Q9UPP1
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9UPP1/entry
  • Mouse_gene_id： 320595
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=320595
  • Mouse_swiss_prot_no： Q80TJ7
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q80TJ7/entry
  • 特異性： This antibody detects endogenous levels of PHF8 at Human, Mouse
  • 組成： Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • 來(lái)源： Polyclonal, Rabbit,IgG
  • 稀釋?zhuān)? WB 1:500-2000 IHC 1:50-200
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書(shū)： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱(chēng)： Histone lysine demethylase PHF8 (EC 1.14.11.27) (PHD finger protein 8)
  • 分子量： 117kD
  • 功能： Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3.
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus . Nucleus, nucleolus . Recruited to H3K4me3 sites on chromatin during interphase (PubMed:20622854). Dissociates from chromatin when cells enter mitosis (PubMed:20622854). .
  • 科研貨號(hào)： PLA021567
PHF8 rabbit pAb
Catalog No PLA021567
Product information
  • 基因名稱(chēng)： PHF8 KIAA1111 ZNF422
  • 蛋白名稱(chēng)： Histone lysine demethylase PHF8 (EC 1.14.11.27) (PHD finger protein 8)
  • Human_gene_id： 23133
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23133
  • Human_swiss_prot_no： Q9UPP1
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9UPP1/entry
  • Mouse_gene_id： 320595
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=320595
  • Mouse_swiss_prot_no： Q80TJ7
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q80TJ7/entry
  • 特異性： This antibody detects endogenous levels of PHF8 at Human, Mouse
  • 組成： Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • 來(lái)源： Polyclonal, Rabbit,IgG
  • 稀釋?zhuān)? WB 1:500-2000 IHC 1:50-200
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書(shū)： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱(chēng)： Histone lysine demethylase PHF8 (EC 1.14.11.27) (PHD finger protein 8)
  • 分子量： 117kD
  • 功能： Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3.
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus . Nucleus, nucleolus . Recruited to H3K4me3 sites on chromatin during interphase (PubMed:20622854). Dissociates from chromatin when cells enter mitosis (PubMed:20622854). .
  • 科研貨號(hào)： PLA021567
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