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NPCL1 rabbit pAb
商品貨號(hào)： PLA021565
適 應(yīng) 性： 人,小鼠,大鼠
WB IHC
￥600元
規(guī)格：
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MSDS
說明書
商品描述
  • 基因名稱： NPC1L1
  • 蛋白名稱： Niemann-Pick C1-like protein 1
  • Human_gene_id： 29881
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29881
  • Human_swiss_prot_no： Q9UHC9
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9UHC9/entry
  • Mouse_gene_id： 237636
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=237636
  • Mouse_swiss_prot_no： Q6T3U4
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q6T3U4/entry
  • Rat_gene_id： 432367
  • Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=432367
  • Rat_swiss_prot_no： Q6T3U3
  • Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q6T3U3/entry
  • 特異性： This antibody detects endogenous levels of NPCL1 at Human, Mouse,Rat
  • 組成： Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1:500-2000 IHC 1:50-200
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： Niemann-Pick C1-like protein 1
  • 分子量： 149kD
  • 功能： Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Apical cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5. .
  • 組織表達(dá)： Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
  • 科研貨號(hào)： PLA021565
NPCL1 rabbit pAb
Catalog No PLA021565
Product information
  • 基因名稱： NPC1L1
  • 蛋白名稱： Niemann-Pick C1-like protein 1
  • Human_gene_id： 29881
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29881
  • Human_swiss_prot_no： Q9UHC9
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9UHC9/entry
  • Mouse_gene_id： 237636
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=237636
  • Mouse_swiss_prot_no： Q6T3U4
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q6T3U4/entry
  • Rat_gene_id： 432367
  • Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=432367
  • Rat_swiss_prot_no： Q6T3U3
  • Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q6T3U3/entry
  • 特異性： This antibody detects endogenous levels of NPCL1 at Human, Mouse,Rat
  • 組成： Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1:500-2000 IHC 1:50-200
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： Niemann-Pick C1-like protein 1
  • 分子量： 149kD
  • 功能： Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Apical cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5. .
  • 組織表達(dá)： Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
  • 科研貨號(hào)： PLA021565
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