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Human LAP ELISA Kit
商品貨號： PLA002302
適 應 性： 人
ELISA
￥600元
規(guī)格：
在線咨詢
MSDS
說明書
商品描述
  • 發(fā)貨日期： 14
  • 基因名稱： TGFB1
  • 蛋白名稱： Transforming growth factor beta-1
  • Human_gene_id： 7040
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7040
  • Human_swiss_prot_no： P01137
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P01137/entry
  • Mouse_swiss_prot_no： P04202
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/P04202
  • 特異性： Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
  • 儲存： 2-8°C/6 months
  • 說明書： KE1150.pdf
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： TGFB1; TGFB; Transforming growth factor beta-1; TGF-beta-1
  • 功能： disease:Defects in TGFB1 are the cause of Camurati-Engelmann disease (CED) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CED is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.,function:Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.,induction:Activated in vitro at pH below 3.5 and over 12.5.,online information:TGF beta-1 entry,polymorphism:In post-menopausal Japanese women, the frequency of Leu-10 is higher in subjects with osteoporosis than in controls.,PTM:Glycosylated.,PTM:The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.,similarity:Belongs to the TGF-beta family.,subunit:The inactive form consists of a TGFB1 homodimer non-covalently linked to a latency-associated peptide (LAP) homodimer. The inactive complex can contain a latent TGFB1-binding protein. The active form is a homodimer of mature TGFB1; disulfide-linked. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT.,tissue specificity:Highly expressed in bone.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix .; [Transforming growth factor beta-1]: Secreted .
  • 組織表達： Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158).
  • 科研貨號： PLA002302
Human LAP ELISA Kit
Catalog No PLA002302
Product information
  • 發(fā)貨日期： 14
  • 基因名稱： TGFB1
  • 蛋白名稱： Transforming growth factor beta-1
  • Human_gene_id： 7040
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7040
  • Human_swiss_prot_no： P01137
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P01137/entry
  • Mouse_swiss_prot_no： P04202
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/P04202
  • 特異性： Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
  • 儲存： 2-8°C/6 months
  • 說明書： KE1150.pdf
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： TGFB1; TGFB; Transforming growth factor beta-1; TGF-beta-1
  • 功能： disease:Defects in TGFB1 are the cause of Camurati-Engelmann disease (CED) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CED is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.,function:Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.,induction:Activated in vitro at pH below 3.5 and over 12.5.,online information:TGF beta-1 entry,polymorphism:In post-menopausal Japanese women, the frequency of Leu-10 is higher in subjects with osteoporosis than in controls.,PTM:Glycosylated.,PTM:The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.,similarity:Belongs to the TGF-beta family.,subunit:The inactive form consists of a TGFB1 homodimer non-covalently linked to a latency-associated peptide (LAP) homodimer. The inactive complex can contain a latent TGFB1-binding protein. The active form is a homodimer of mature TGFB1; disulfide-linked. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT.,tissue specificity:Highly expressed in bone.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix .; [Transforming growth factor beta-1]: Secreted .
  • 組織表達： Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158).
  • 科研貨號： PLA002302
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