功能: cytokine production,?response to molecule of bacterial origin,?transcription,?transcription, DNA-dependent,?regulation of transcription, DNA-dependent,?transcription from RNA polymerase II promoter,?cell surface receptor linked signal transduction,?intracellular signaling cascade,?protein kinase cascade,?I-kappaB kinase/NF-kappaB cascade,?response to virus,?response to bacterium,?response to organic substance,?lipopolysaccharide-mediated signaling pathway,response to lipopolysaccharide,?type I interferon production,?RNA biosynthetic process,?cytokine biosynthetic process,cytokine metabolic process,?response to exogenous dsRNA,?response to dsRNA,?type I interferon biosynthetic process,regulation of transcription,?regulation of RNA metabolic process,
細胞定位: Cytoplasm . Nucleus . Mitochondrion . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). .
組織表達: Expressed constitutively in a variety of tissues.
功能: cytokine production,?response to molecule of bacterial origin,?transcription,?transcription, DNA-dependent,?regulation of transcription, DNA-dependent,?transcription from RNA polymerase II promoter,?cell surface receptor linked signal transduction,?intracellular signaling cascade,?protein kinase cascade,?I-kappaB kinase/NF-kappaB cascade,?response to virus,?response to bacterium,?response to organic substance,?lipopolysaccharide-mediated signaling pathway,response to lipopolysaccharide,?type I interferon production,?RNA biosynthetic process,?cytokine biosynthetic process,cytokine metabolic process,?response to exogenous dsRNA,?response to dsRNA,?type I interferon biosynthetic process,regulation of transcription,?regulation of RNA metabolic process,
細胞定位: Cytoplasm . Nucleus . Mitochondrion . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). .
組織表達: Expressed constitutively in a variety of tissues.
科研貨號: PLA001939
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