功能: generation of precursor metabolites and energy,?transcription,?transcription, DNA-dependent,?regulation of transcription, DNA-dependent,?transcription from RNA polymerase II promoter,?defense response,?inflammatory response,?heart development,?response to wounding,?energy derivation by oxidation of organic compounds,?RNA biosynthetic process,?cellular respiration,?regulation of transcription,?regulation of RNA metabolic process,
細(xì)胞定位: Cytoplasm, cytosol . Nucleus . When hyperphosphorylated, localizes in the cytosol. When intracellular Ca(2+) levels increase, dephosphorylation by calcineurin/PPP3CA leads to translocation into the nucleus (PubMed:11997522, PubMed:18347059). MAPK7/ERK5 and MTOR regulate NFATC4 nuclear export through phosphorylation at Ser-168 and Ser-170 (PubMed:18347059). .
組織表達(dá): Widely expressed, with high levels in placenta, lung, kidney, testis and ovary (PubMed:18675896). Weakly expressed in spleen and thymus (PubMed:18675896). In the hippocampus, expressed in the granular layer of the dentate gyrus, in the pyramidal neurons of CA3 region, and in the hippocampal fissure (PubMed:18675896). Expressed in the heart (at protein level) (PubMed:12370307).
功能: generation of precursor metabolites and energy,?transcription,?transcription, DNA-dependent,?regulation of transcription, DNA-dependent,?transcription from RNA polymerase II promoter,?defense response,?inflammatory response,?heart development,?response to wounding,?energy derivation by oxidation of organic compounds,?RNA biosynthetic process,?cellular respiration,?regulation of transcription,?regulation of RNA metabolic process,
細(xì)胞定位: Cytoplasm, cytosol . Nucleus . When hyperphosphorylated, localizes in the cytosol. When intracellular Ca(2+) levels increase, dephosphorylation by calcineurin/PPP3CA leads to translocation into the nucleus (PubMed:11997522, PubMed:18347059). MAPK7/ERK5 and MTOR regulate NFATC4 nuclear export through phosphorylation at Ser-168 and Ser-170 (PubMed:18347059). .
組織表達(dá): Widely expressed, with high levels in placenta, lung, kidney, testis and ovary (PubMed:18675896). Weakly expressed in spleen and thymus (PubMed:18675896). In the hippocampus, expressed in the granular layer of the dentate gyrus, in the pyramidal neurons of CA3 region, and in the hippocampal fissure (PubMed:18675896). Expressed in the heart (at protein level) (PubMed:12370307).
科研貨號(hào): PLA000308
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