功能: protein amino acid phosphorylation,?phosphorus metabolic process,?phosphate metabolic process,?induction of apoptosis,?intracellular signaling cascade,?protein kinase cascade,?I-kappaB kinase/NF-kappaB cascade,?mesoderm development,?induction of apoptosis by extracellular signals,?regulation of cell death,?positive regulation of cell death,induction of programmed cell death,?phosphorylation,?peptidyl-tyrosine phosphorylation,?peptidyl-tyrosine modification,?calcium-mediated signaling,?second-messenger-mediated signaling,?developmental maturation,regulation of apoptosis,?positive regulation of apoptosis,?regulation of programmed cell death,?positive regulation of programmed cell death,?cell maturation,
細(xì)胞定位: Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1.
組織表達(dá): Predominantly expressed in B-lymphocytes.
功能: protein amino acid phosphorylation,?phosphorus metabolic process,?phosphate metabolic process,?induction of apoptosis,?intracellular signaling cascade,?protein kinase cascade,?I-kappaB kinase/NF-kappaB cascade,?mesoderm development,?induction of apoptosis by extracellular signals,?regulation of cell death,?positive regulation of cell death,induction of programmed cell death,?phosphorylation,?peptidyl-tyrosine phosphorylation,?peptidyl-tyrosine modification,?calcium-mediated signaling,?second-messenger-mediated signaling,?developmental maturation,regulation of apoptosis,?positive regulation of apoptosis,?regulation of programmed cell death,?positive regulation of programmed cell death,?cell maturation,
細(xì)胞定位: Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1.
組織表達(dá): Predominantly expressed in B-lymphocytes.
科研貨號(hào): PLA000041
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